Proposal: “Development of Bivalent Live Recombinant Vaccine Against Brucellosis and Anthrax” Project Manager: Anatoly N. Noskov, MD Objective: Development of a live bivalent vaccine against brucellosis and anthrax for veterinary use. Reviewer: Matthew Meselson
نویسنده
چکیده
This is a proposal to modify vaccine strains of B. anthracis (strains ST1 and Sterne) by introducing into them plasmids that code for fusion proteins intended to confer immunity both to anthrax and to brucellosis. The resulting live bivalent vaccine would then replace the live monovalent anthrax vaccines currently in use. DESCRIPTION Brucellosis is a debilitating although seldom lethal bacterial disease caused by certain strains of Brucella. Its principal reservoirs are cattle, sheep and swine. Human exposure is principally from direct contact with infected animals and animal products, including the consumption of unpasteurized milk and milk products from infected animals. Control of the disease in humans is mainly by avoiding consumption of unpasteurized milk and milk products and contact with infected animals, by sacrifice of infected animals and herds, and, in areas where brucellosis is endemic, veterinary
منابع مشابه
A review of prophylactic measure against brucellosis in human with a live attenuated vaccine
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A Bivalent Anthrax–Plague Vaccine That Can Protect against Two Tier-1 Bioterror Pathogens, Bacillus anthracis and Yersinia pestis
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In Silico Prediction of B-Cell and T-Cell Epitopes of Protective Antigen of Bacillus anthracis in Development of Vaccines Against Anthrax
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